This is potentially exciting news.

Advanced prostate cancer often becomes resistant to treatment with hormone therapies as it advances, and this recent discovery by researchers at the University of Chicago suggests that there may be a way to reverse that resistance:

Current treatment options for treatment-resistant neuroendocrine prostate cancer are largely limited to platinum-based chemotherapies, which offer modest survival benefits. The discovery that tRNA modulation can reverse lineage switching suggests that RNA-targeted therapeutics such as synthetic tRNA mimics or small molecules that enhance tRNAArg (UCU)-1 production, could re-sensitize hard-to-treat tumors to existing, widely available androgen receptor-targeted drugs.

You can find the press release here (it contains a link to the original paper):

https://biologicalsciences.uchicago.edu/news/mechanism-therapy-resistance-prostate-cancer

Of course, it will take years to develop this and get this to patients, but it is promising.

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